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KMID : 0857020090240020203
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Kosin Medical Journal
2009 Volume.24 No. 2 p.203 ~ p.206
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A Case of Intraveous Immunoglobulin Treatment in IgG3 Deficient with Asthma
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Kim Hee-Kyoo
Oak Chul-Ho
Jung Maan-Hong
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Abstract
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Asthma is precipitated into acute episode of airway obstruction by respiratory infection. Also, some immunological abnormalities including deficiencies of IgG subclasses are reported in patients with asthma. A 65 year old woman, who has a 20 years history of bronchial asthma and allergic rhinitis, has been suffering from recurrent upper and lower respiratory infection for 2 years. She has been admitted frequently by asthma exacerbation. We evaluated her immunoglobulin level. IgG subclass III level was reduced at 14.3 mg/dl (normal range 23.0~196.0 mg/dl) with other IgG subclass profiles in the normal range. So, we administrated IVIG (intravenous immunoglobulin) monthly 0.4 g/kg dose for symptomatic IgG3 deficiency. She was much improved in clinical course : without asthma exacerbation, recurrent respiratory infection, and need for antibiotics. So, the symptomatic IgG subclass deficient patients may be candidates for IVIG replacement.
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KEYWORD
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Asthma, Immune deficiency, Immunoglobulin
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